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Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents

Ginty, F; Cavadini, C; Michaud, PA; Burckhardt, P; Baumgartner, M; Mishra, GD; Barclay, DV; (2004) Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents. Eur.J.Clin.Nutr. , 58 (9) pp. 1257-1265.

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Abstract

OBJECTIVE: To evaluate the effects of nutrient intake and vitamin D status on markers of type I collagen formation and degradation in adolescent boys and girls. DESIGN: Cross-sectional study. SETTING: Canton of Vaud, West Switzerland. SUBJECTS: A total of 92 boys and 104 girls, aged 11-16 y. Data were collected on height, weight, pubertal status (self-assessment of Tanner stage), nutrient intake (3-day dietary record) and fasting serum concentration of 25-hydroxyvitamin D (25OHD), and markers of collagen formation (P1NP) and degradation (serum C-terminal telopeptides: S-CTX). RESULTS: Tanner stage was a significant determinant of P1NP in boys and girls and S-CTX in girls. Of the nutrients examined, only the ratio of calcium to phosphorus (Ca/P) was positively associated with P1NP in boys, after adjustment for pubertal status. 25OHD decreased significantly at each Tanner stage in boys. Overall, 15% of boys and 17% of girls were identified as being vitamin D insufficient (serum 25OHD <30 nmol/l), with the highest proportion of insufficiency at Tanner stage 4-5 (29%) in boys and at Tanner stage 3 (24%) in girls. A significant association was not found between 25OHD and either bone turnover marker, nor was 25OHD insufficiency associated with higher concentrations of the bone turnover markers. CONCLUSIONS: The marked effects of puberty on bone metabolism may have obscured any possible effects of diet and vitamin D status on markers of bone metabolism. The mechanistic basis for the positive association between dietary Ca/P ratio and P1NP in boys is not clear and may be attributable to a higher Ca intake per se, a critical balance between Ca and P intake or higher dairy product consumption. A higher incidence of vitamin D insufficiency in older adolescents may reflect a more sedentary lifestyle or increased utilisation of 25OHD, and suggests that further research is needed to define their requirements. SPONSORSHIP: Nestec Ltd and The Swiss Foundation for Research in Osteoporosis

Type: Article
Title: Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents
Additional information: DA - 20040826IS - 0954-3007 (Print)LA - engPT - Journal ArticleRN - 0 (Peptide Fragments)RN - 0 (Procollagen)RN - 0 (procollagen type I carboxy terminal peptide)RN - 1406-16-2 (Vitamin D)RN - 64719-49-9 (25-hydroxyvitamin D)RN - 7440-70-2 (Calcium)RN - 7723-14-0 (Phosphorus)RN - 9007-34-5 (Collagen)SB - IMCV: 63
Keywords: administration & dosage, Adolescent, Aged, analogs & derivatives, blood, Bone and Bones, Calcium, Child, Collagen, CONSUMPTION, Cross-Sectional Studies, diagnosis, Diet, Diet Records, epidemiology, Female, Food Habits, Humans, Incidence, Male, metabolism, Nutritional Requirements, Nutritional Status, Peptide Fragments, Phosphorus, Procollagen, Puberty, Switzerland, Vitamin D, Vitamin D Deficiency
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/51937
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