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Management of pregnancy when maternal blood has a very high level of fetal haemoglobin.

Kaeda, JS; Prasad, K; Howard, RJ; Mehta, A; Vulliamy, T; Luzzatto, L; (1994) Management of pregnancy when maternal blood has a very high level of fetal haemoglobin. Br J Haematol , 88 (2) pp. 432-434.

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Abstract

Fetal blood normally has a higher oxygen affinity than maternal blood because of the predominance of haemoglobin (Hb) F in the former and of Hb A in the latter; this predominance facilitates the transfer of oxygen from maternal to fetal blood. We report two patients who had exclusively or predominantly Hb F in their blood and were managed differently. When patient 1 became pregnant she had regular exchange blood transfusions in order to reduce her Hb F from 80% to below 50%; patient 2, who had 100% Hb F, was not transfused before, during or after her pregnancy. Each patient delivered a normal healthy baby. We conclude that the differential oxygen affinity produced by the combination of Hb A in the maternal blood and Hb F in the fetal blood is not indispensable to ensure an oxygen supply adequate for normal fetal development and growth.

Type: Article
Title: Management of pregnancy when maternal blood has a very high level of fetal haemoglobin.
Location: England
Keywords: Adult, Blood Transfusion, Female, Fetal Hemoglobin, Genotype, Globins, Humans, Mutation, Oxygen, Pregnancy, Pregnancy Complications, Hematologic, Pregnancy Outcome, Prenatal Care, beta-Thalassemia
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/50326
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