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Diagnosis and management of the neurological complications of falciparum malaria

Mishra, SK; Newton, CRJC; (2009) Diagnosis and management of the neurological complications of falciparum malaria. Nature Reviews Neurology , 5 (4) 189 - 198.

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Abstract

Malaria is a major public health problem in the developing world owing to its high rates of morbidity and mortality. Of all the malarial parasites that infect humans, Plasmodium falciparum is most commonly associated with neurological complications, which manifest as agitation, psychosis, seizures, impaired consciousness and coma (cerebral malaria). Cerebral malaria is the most severe neurological complication; the condition is associated with mortality of 15-20%, and a substantial proportion of individuals with this condition develop neurocognitive sequelae. in this review, we describe the various neurological complications encountered in malaria, discuss the underlying pathogenesis, and outline current management strategies for these complications. Furthermore, we discuss the role of adjunctive therapies in improving outcome

Type:Article
Title:Diagnosis and management of the neurological complications of falciparum malaria
Additional information:WoS ID: 000265854600006 JAPR
Keywords:complications, diagnosis, health, Humans, mortality, therapy
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health

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