UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Primary herpes simplex virus type-2 infection as a cause of liver failure after liver transplantation

Nebbia, G; Mattes, FM; Ramaswamy, M; Quaglia, A; Verghese, G; Griffiths, PD; ... Geretti, AM; + view all (2006) Primary herpes simplex virus type-2 infection as a cause of liver failure after liver transplantation. TRANSPL INFECT DIS , 8 (4) 229 - 232. 10.1111/j.1399-3062.2006.00144.x.

Full text not available from this repository.

Abstract

We report a case of fatal primary herpes simplex virus type-2 (HSV-2) infection following liver transplantation, which manifested with fever and liver failure in the absence of mucocutaneous disease. The infection was characterized by high levels of HSV DNA in blood and the patient's inability to mount HSV-specific T-cell responses while showing preserved T-cell responses against cytomegalovirus. The donor was HSV-1 immunoglobulin G (IgG) seronegative and HSV-2 IgG seropositive, whereas the recipient was HSV-1 and HSV-2 IgG seronegative, suggesting that the graft may have been the source of the infection. In HSV-seronegative recipients of grafts from HSV-seropositive donors, HSV infection should be included in the differential diagnosis of a febrile illness, regardless of the absence of muco-cutaneous disease. In this setting, real-time polymerase chain reaction applied to blood samples provides a sensitive, rapid, and quantitative diagnostic tool.

Type:Article
Title:Primary herpes simplex virus type-2 infection as a cause of liver failure after liver transplantation
DOI:10.1111/j.1399-3062.2006.00144.x
Keywords:HSV, transplantation, liver failure, RENAL-TRANSPLANTATION, TRANSMISSION, ORGAN, RECIPIENTS, HSV-1
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of) > Research Department of Infection

Archive Staff Only: edit this record