PILLAY, D; CHARMAN, H; BURROUGHS, AK; SMITH, M; ROLLES, K; GRIFFITHS, PD; (1992) SURVEILLANCE FOR CMV INFECTION IN ORTHOTOPIC LIVER-TRANSPLANT RECIPIENTS. TRANSPLANTATION , 53 (6) 1261 - 1265.
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Infection with cytomegalovirus is a major cause of morbidity and mortality following orthotopic liver transplantation. In order that preventive strategies may be devised, a detailed assessment of risk factors for infection and disease is required. We have prospectively assessed 46 orthotopic liver transplant recipients for CMV excretion from multiples sites in order to determine incidence of, and risk factors for, CMV infection and disease. Risk factors for posttransplant CMV infection were donor CMV seropositivity, an increased volume of peritransplant whole-blood transfusion and an increased dose of extra steroid therapy to treat rejection episodes. These findings implicate, respectively, transfer of virus with donor organ, transfer of virus with blood transfusion, and stimulation of reactivation of latent virus in recipients through augmented immunosuppression. The possible ways of preventing or ameliorating these effects are discussed.
|Title:||SURVEILLANCE FOR CMV INFECTION IN ORTHOTOPIC LIVER-TRANSPLANT RECIPIENTS|
|Keywords:||CYTOMEGALO-VIRUS INFECTION, MARROW TRANSPLANTATION, MULTIVARIATE-ANALYSIS, IMMUNE GLOBULIN, RAPID DIAGNOSIS, IGG ANTIBODIES, RISK-FACTORS, DISEASE, RADIOIMMUNOASSAY, REACTIVATION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of) > Research Department of Infection|
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