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Medical management of bleeding esophageal varices.

Burroughs, AK; (1992) Medical management of bleeding esophageal varices. Dig Dis , 10 Sup pp. 30-37. 10.1159/000171385.

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Vasoactive drug therapy is the only therapy that can be administered immediately to patients with suspected variceal bleeding. The optimal agent is not yet available, but somatostatin or octreotide, glypressin and vasopressin and nitroglycerin are the best candidates. Somatostatin and octreotide have the best therapeutic index as they have very few side effects. They compare well to the other agents in comparative randomized trials. In addition to being used prior to sclerotherapy, vasoactive agents may show benefit when used in combination with endoscopic methods and in the immediate interval thereafter in order to prevent early re-bleeding. This remains to be tested in clinical trials.

Type: Article
Title: Medical management of bleeding esophageal varices.
Location: Switzerland
DOI: 10.1159/000171385
Keywords: Drug Therapy, Combination, Esophageal and Gastric Varices, Gastrointestinal Hemorrhage, Humans, Octreotide, Somatostatin, Vasoconstrictor Agents
URI: http://discovery.ucl.ac.uk/id/eprint/493695
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