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Severe venoocclusive disease after liver transplantation treated with transjugular intrahepatic portosystemic shunt.

Senzolo, M; Patch, D; Cholongitas, E; Triantos, C; Marelli, L; Stigliano, R; Dhillon, A; (2006) Severe venoocclusive disease after liver transplantation treated with transjugular intrahepatic portosystemic shunt. Transplantation , 82 (1) pp. 132-135. 10.1097/01.tp.0000225799.76828.ce.

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Abstract

Venoocclusive disease (VOD) is due to hepatic sinusoidal lining injury leading to portal hypertension; its incidence after liver transplantation is about 2%. When severe, it does not respond to medical therapy and has a high mortality; retransplantation is the only therapeutic option. However, there are no detailed data regarding the use of transjugular intrahepatic portosystemic shunt for VOD after liver transplantation. We describe two patients who developed severe VOD after liver transplantation, failed defibrotide therapy, and were treated by transjugular intrahepatic portosystemic shunt (TIPS). The portal hypertension resolved completely and one had full histological recovery. We believe that TIPS should be attempted as it may resolve progressive portal hypertension and the hepatic congestion, while allowing the clinician time for listing for further liver transplantation if the patient fails to respond.

Type: Article
Title: Severe venoocclusive disease after liver transplantation treated with transjugular intrahepatic portosystemic shunt.
Location: United States
DOI: 10.1097/01.tp.0000225799.76828.ce
Keywords: Female, Hepatic Veno-Occlusive Disease, Humans, Liver Transplantation, Male, Middle Aged, Portasystemic Shunt, Transjugular Intrahepatic, Treatment Outcome
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/493674
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