UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Severe venoocclusive disease after liver transplantation treated with transjugular intrahepatic portosystemic shunt.

Senzolo, M; Patch, D; Cholongitas, E; Triantos, C; Marelli, L; Stigliano, R; ... Burroughs, A; + view all (2006) Severe venoocclusive disease after liver transplantation treated with transjugular intrahepatic portosystemic shunt. Transplantation , 82 (1) 132 - 135. 10.1097/01.tp.0000225799.76828.ce.

Full text not available from this repository.

Abstract

Venoocclusive disease (VOD) is due to hepatic sinusoidal lining injury leading to portal hypertension; its incidence after liver transplantation is about 2%. When severe, it does not respond to medical therapy and has a high mortality; retransplantation is the only therapeutic option. However, there are no detailed data regarding the use of transjugular intrahepatic portosystemic shunt for VOD after liver transplantation. We describe two patients who developed severe VOD after liver transplantation, failed defibrotide therapy, and were treated by transjugular intrahepatic portosystemic shunt (TIPS). The portal hypertension resolved completely and one had full histological recovery. We believe that TIPS should be attempted as it may resolve progressive portal hypertension and the hepatic congestion, while allowing the clinician time for listing for further liver transplantation if the patient fails to respond.

Type:Article
Title:Severe venoocclusive disease after liver transplantation treated with transjugular intrahepatic portosystemic shunt.
Location:United States
DOI:10.1097/01.tp.0000225799.76828.ce
Language:English
Keywords:Female, Hepatic Veno-Occlusive Disease, Humans, Liver Transplantation, Male, Middle Aged, Portasystemic Shunt, Transjugular Intrahepatic, Treatment Outcome

Archive Staff Only: edit this record