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Adult "idiopathic" extrahepatic venous thrombosis. Importance of putative "latent" myeloproliferative disorders and comparison with cases with known etiology.

Cardin, F; Graffeo, M; McCormick, PA; McIntyre, N; Burroughs, A; (1992) Adult "idiopathic" extrahepatic venous thrombosis. Importance of putative "latent" myeloproliferative disorders and comparison with cases with known etiology. Dig Dis Sci , 37 (3) 335 - 339.

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Abstract

The etiology of extrahepatic venous obstruction (EHVO) is unknown in 50% of cases. Recently the presence of a "latent" myeloproliferative disorder has been reported in adults with "idiopathic" EHVO. We evaluated the course of these patients to establish if any putative latent myeloproliferative disorder influenced the clinical course compared to those with a known cause. Among 132 EHVO patients, 78 (59%) had a known etiology, 7 (5%) with an overt myeloproliferative disorder. The "idiopathic" group had 54 patients; 24 (13 men, 11 women) were diagnosed after 15 years of age, (median 38 years, range 17-70) with a median follow up of 96 months (19-372). Only 2 (8%) developed an overt myeloproliferative disorder. These 24 had a similar pattern of bleeding and onset of ascites as those with known cause. In EHVO failure to diagnose a latent myeloproliferative disorder does not influence the course of variceal bleeding, and thus has little prognostic significance.

Type:Article
Title:Adult "idiopathic" extrahepatic venous thrombosis. Importance of putative "latent" myeloproliferative disorders and comparison with cases with known etiology.
Location:UNITED STATES
Language:English
Keywords:Adolescent, Adult, Aged, Cause of Death, Child, Child, Preschool, Esophageal and Gastric Varices, Female, Follow-Up Studies, Gastrointestinal Hemorrhage, Humans, Hypertension, Portal, Infant, Male, Middle Aged, Myeloproliferative Disorders, Portal Vein, Prognosis, Recurrence, Splenomegaly, Survival Rate, Thrombosis

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