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SUBCLINICAL ADDISONS-DISEASE - A CAUSE OF PERSISTENT ABNORMALITIES IN TRANSAMINASE VALUES

BOULTON, R; HAMILTON, MI; DHILLON, AP; KINLOCH, JD; BURROUGHS, AK; (1995) SUBCLINICAL ADDISONS-DISEASE - A CAUSE OF PERSISTENT ABNORMALITIES IN TRANSAMINASE VALUES. GASTROENTEROLOGY , 109 (4) 1324 - 1327.

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Abstract

A common reason for referring patients to hepatologists is persistently abnormal serum transaminase levels with vague constitutional symptoms. In the United Kingdom, these abnormalities are most often caused by a fatty liver either related to obesity or alcohol abuse; they are less commonly caused by chronic liver disease, particularly chronic viral hepatitis, autoimmune hepatitis, or chronic biliary disease. Endocrine disease is rarely a cause of these abnormalities, although hypothyroidism and hyperthyroidism are well-recognized causes. Addison's disease has been only reported once in the literature by R. G. Olsson as a cause of increased transaminase levels associated with constitutional symptoms; it is not mentioned in textbooks on hepatology. Three patients with Addison's disease are reported here, all of whom had increased serum transaminase levels for more than 6 months before the recognition of the hypoadrenalism with resolution to normal after steroid replacement. Hepatologists should consider subclinical Addison's disease as a cause of persistently increased transaminase levels with constitutional symptoms in the absence of evidence for fatty liver as well as viral and autoimmune markers.

Type:Article
Title:SUBCLINICAL ADDISONS-DISEASE - A CAUSE OF PERSISTENT ABNORMALITIES IN TRANSAMINASE VALUES
Keywords:LIVER
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Pathology

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