BOULTON, R and HAMILTON, MI and DHILLON, AP and KINLOCH, JD and BURROUGHS, AK (1995) SUBCLINICAL ADDISONS-DISEASE - A CAUSE OF PERSISTENT ABNORMALITIES IN TRANSAMINASE VALUES. GASTROENTEROLOGY , 109 (4) 1324 - 1327.
Full text not available from this repository.
A common reason for referring patients to hepatologists is persistently abnormal serum transaminase levels with vague constitutional symptoms. In the United Kingdom, these abnormalities are most often caused by a fatty liver either related to obesity or alcohol abuse; they are less commonly caused by chronic liver disease, particularly chronic viral hepatitis, autoimmune hepatitis, or chronic biliary disease. Endocrine disease is rarely a cause of these abnormalities, although hypothyroidism and hyperthyroidism are well-recognized causes. Addison's disease has been only reported once in the literature by R. G. Olsson as a cause of increased transaminase levels associated with constitutional symptoms; it is not mentioned in textbooks on hepatology. Three patients with Addison's disease are reported here, all of whom had increased serum transaminase levels for more than 6 months before the recognition of the hypoadrenalism with resolution to normal after steroid replacement. Hepatologists should consider subclinical Addison's disease as a cause of persistently increased transaminase levels with constitutional symptoms in the absence of evidence for fatty liver as well as viral and autoimmune markers.
|Title:||SUBCLINICAL ADDISONS-DISEASE - A CAUSE OF PERSISTENT ABNORMALITIES IN TRANSAMINASE VALUES|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Pathology
Archive Staff Only: edit this record