UCL Discovery

Abstract

Background-The detection of hepatocellular cancers (HCC) is a major role of preoperative imaging in patients with end stage liver disease being considered for orthotopic liver transplantation (OLT).Aims-To assess the sensitivity of iodised oil computed tomography (IOCT).Patients and methods-A prospective evaluation in 50 consecutive patients undergoing OLT included ultrasound scan, contrast enhanced CT, angiography (with intra-arterial injection of iodised oil), and se second CT (IOCT) 10 days later. Following transplantation the explant liver was serially sectioned for pathological evaluation. Soft tissue radiographs of a-he liver slices were used to match histological lesions with CT findings. Results-Eleven patients were excluded due to protocol violations, Of the remaining 39, histological evaluation revealed no cancers is 33 explant livers, in keeping with negative preoperative imaging, Six explant livers contained 55 HCCs, 84% of which were less than 1 cm in diameter. Pretransplant IOCT detected 315 patients with cancer (50% but only 7% of cancerous lesions. Ultrasound, contrast CT, and angiography each detected 2/6 patients with cancer and 4% of cancerous lesions.Conclusions-IOCT is an insensitive method for the detection of small HCCs in livers with advanced cirrhosis brat: in this study was slightly superior to ultrasound, CT, and angiography.