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Treatment of alcohol-related liver disease with thioctic acid: a six month randomised double-blind trial.

Marshall, AW; Graul, RS; Morgan, MY; Sherlock, S; (1982) Treatment of alcohol-related liver disease with thioctic acid: a six month randomised double-blind trial. Gut , 23 (12) pp. 1088-1093. 10.1136/gut.23.12.1088.

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Abstract

A randomised double-blind trial of thioctic acid (alpha-lipoic acid), 300 mg/day versus placebo was carried out in 40 patients with pre-cirrhotic alcohol-related liver disease over a six month period. Twenty patients received the active drug and 20 placebo. Twenty-two of the 40 patients (55%) abstained from alcohol and showed significant improvements (p less than 0.01) in mean values for serum aspartate transaminase, serum glutamyl transpeptidase, and mean corpuscular volume. Seventeen of the 22 (77%) showed overall histological improvement on liver biopsy. The remaining 18 patients (45%) continued to drink but significantly reduced their mean daily alcohol intake (p less than 0.001). No significant changes occurred in their laboratory indices, but five of the 18 (28%) showed overall histological improvement. Changes occurred irrespective of treatment with thioctic acid, which suggested that, over six months, this drug did not influence the course of alcohol-related liver disease.

Type: Article
Title: Treatment of alcohol-related liver disease with thioctic acid: a six month randomised double-blind trial.
Location: England
DOI: 10.1136/gut.23.12.1088
Keywords: Adult, Aspartate Aminotransferases, Blood Volume, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Liver, Liver Diseases, Alcoholic, Male, Middle Aged, Random Allocation, Thioctic Acid, gamma-Glutamyltransferase
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/49320
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