UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Gut mucosal response to food antigens in Crohn's disease.

Van Den Bogaerde, J; Cahill, J; Emmanuel, AV; Vaizey, CJ; Talbot, IC; Knight, SC; Kamm, MA; (2002) Gut mucosal response to food antigens in Crohn's disease. Aliment Pharmacol Ther , 16 (11) pp. 1903-1915.

Full text not available from this repository.

Abstract

BACKGROUND: Food antigens may contribute to gut inflammation in Crohn's disease. AIM: To assess in vivo sensitization to food antigens, ascertain whether sensitivity is gut specific, assess food sensitization in vitro, and correlate in vivo changes with histological and blood changes. METHODS: Skin testing and rectal exposure to six food antigens (cereal, cabbage, citrus, milk, yeast and peanut) and control saline were assessed double-blind by immediate and 3.5-h laser Doppler blood flowmetry, and rectal biopsies were taken. Peripheral blood lymphocyte proliferation was measured in response to the same antigens. RESULTS: Ten patients with Crohn's disease and 10 healthy controls were studied. Blood flow increased in 24 of 60 antigen sites in Crohn's disease patients and six of 60 antigen sites in controls (P < 0.0001) after 3.5 h. The Crohn's disease group demonstrated higher rectal blood flow than controls in response to all food antigens, and this was significantly different for the responses to yeast (P = 0.036) and citrus fruits (P = 0.038). Lymphocyte proliferation occurred in 32 of 60 tests in Crohn's disease patients and eight of 60 tests in controls (P < 0.0001). There were no skin responses. Submucosal oedema corresponded to increased mucosal flow. CONCLUSIONS: Crohn's disease patients demonstrate in vivo and in vitro sensitization to food antigens, which is gut specific. Mucosal flowmetry allows the identification of sensitization to gut antigens.

Type: Article
Title: Gut mucosal response to food antigens in Crohn's disease.
Location: England
Keywords: Adult, Allergens, Cell Culture Techniques, Cell Division, Crohn Disease, Double-Blind Method, Female, Food Hypersensitivity, Humans, Intestinal Mucosa, Laser-Doppler Flowmetry, Lymphocyte Activation, Lymphocytes, Male, Middle Aged, Rectum, Regional Blood Flow, Skin, Skin Tests
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/49072
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item