Gross, JG; Morgan, JE; (1999) Muscle precursor cells injected into irradiated mdx mouse muscle persist after serial injury. Muscle Nerve , 22 (2) 174 - 185.
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Muscle of donor origin was formed after implantation of H-2Kb-tsA58 muscle precursor cells (mpc) into irradiated mdx nu/nu mouse muscles. A series of injections of the myotoxin, notexin, which destroys mature muscle fibers but spares muscle precursor cells and other tissues, was made into the mpc-injected muscles, leaving time for regeneration to occur between each injection. New muscle fibers of donor origin were formed after up to four notexin treatments, providing evidence that some of the implanted mpc reentered an undifferentiated, quiescent, stem cell-like state and were capable of myogenesis after further injuries to the muscle. A similar model could be used to assay whether preparations of human mpc contain long-lasting precursor cells, prior to their implantation into patients. In control mdx muscles, which had been irradiated, injected with tissue culture medium, and given three notexin injections, regeneration also occurred, indicating that radiation-resistant mpc were present, presumably within the treated muscle
|Title:||Muscle precursor cells injected into irradiated mdx mouse muscle persist after serial injury|
|Additional information:||DA - 19990324IS - 0148-639X (Print)LA - engPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tRN - 0 (Elapid Venoms)RN - 0 (Neurotoxins)RN - 37223-96-4 (notexin)RN - EC 126.96.36.199 (Myosins)SB - IM|
|Keywords:||Animals, Animals, Newborn, Cell Count, Cell Transplantation, Cells, Cultured, Clone Cells, drug effects, Elapid Venoms, Female, Immunohistochemistry, Injections, injuries, Male, metabolism, Mice, Mice, Inbred C57BL, Mice, Inbred mdx, Mice, Nude, Muscle Fibers, Skeletal, Muscle, Skeletal, Muscles, Myosins, Neurotoxins, pathology, pharmacology, physiology, Pilot Projects, radiation effects, Regeneration, Stem Cell Transplantation, Time Factors|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Neurosciences and Mental Health > ICH - Dubowitz Neuromuscular Centre|
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