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TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system.

Rindi, G; Klöppel, G; Alhman, H; Caplin, M; Couvelard, A; de Herder, WW; Erikssson, B; (2006) TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch , 449 (4) 395 - 401. 10.1007/s00428-006-0250-1.

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Abstract

The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.

Type: Article
Title: TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system.
Location: Germany
DOI: 10.1007/s00428-006-0250-1
Language: English
Keywords: Digestive System Neoplasms, Humans, Lymph Nodes, Mitotic Index, Neoplasm Metastasis, Neoplasm Staging, Neuroendocrine Tumors, Tumor Markers, Biological
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/47967
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