UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Structural heart defects associated with an increased nuchal translucency: 9 years experience in a referral centre.

Clur, SA; Mathijssen, IB; Pajkrt, E; Cook, A; Laurini, RN; Ottenkamp, J; Bilardo, CM; (2008) Structural heart defects associated with an increased nuchal translucency: 9 years experience in a referral centre. Prenat Diagn , 28 (4) pp. 347-354. 10.1002/pd.1985.

Full text not available from this repository.

Abstract

OBJECTIVE: To investigate the congenital heart disease (CHD) found in association with an increased nuchal translucency (NT) at 11-14 weeks of gestation in chromosomally normal and abnormal fetuses. METHODS: Patients referred from January 1998 until May 2007 with an increased NT (> or = 95th percentile) where CHD was diagnosed were included. Chromosome analysis, fetal and postnatal echocardiography were performed. A postmortem examination followed pregnancy termination when possible. RESULTS: Major CHD was identified in 68 of 967 fetuses with an increased NT (median NT 4.8 mm, range 2.5-22 mm). Major CHD was found in 34 of 693 fetuses (4.9%) with a normal karyotype and increased NT (median 5.2 mm, range 2.5-9.6 mm). CHD frequency increased from 1.9%, with NT between 2.5 and 3.5 mm, to 27.7% when NT was > or = 6.5 mm. Septal defects predominated (20%) when NT was < or = 3.5 mm. With NT > 3.5 mm an equal distribution of CHD types was seen. Major CHD was identified in 34 of the 274 fetuses with an abnormal karyotype and increased NT (median 4.2 mm, range 2.5-22 mm). CONCLUSIONS: A variety of CHD is associated with an increased NT in the first trimester of pregnancy. Conotruncal defects, branchial arch derivative defects, left and right obstructive lesions (inflow and outflow) and shunts were seen.

Type: Article
Title: Structural heart defects associated with an increased nuchal translucency: 9 years experience in a referral centre.
Location: England
DOI: 10.1002/pd.1985
Keywords: Abnormalities, Multiple, Chromosome Aberrations, Chromosomes, Human, Pair 18, Chromosomes, Human, X, Down Syndrome, Female, Heart Defects, Congenital, Humans, Monosomy, Nuchal Translucency Measurement, Pregnancy, Referral and Consultation, Retrospective Studies, Trisomy, Ultrasonography, Prenatal
UCL classification: UCL > Office of the President and Provost
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/47578
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item