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Engineered single chain antibody fragments for radioimmunotherapy.

Huhalov, A; Chester, KA; (2004) Engineered single chain antibody fragments for radioimmunotherapy. Q J Nucl Med Mol Imaging , 48 (4) pp. 279-288.

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Abstract

An ideal molecule to deliver radioimmunotherapy (RIT) would be target specific and have prolonged residence time at high concentrations in the tumour with rapid clearance from normal tissues. It would also be non-immunogenic. These features can be rationally introduced into recombinant antibody-based proteins using antibody engineering techniques. This review focuses on the use of antibody engineering in the design and development of RIT molecules which have single chain Fv (scFv) antibody fragments as building blocks.

Type: Article
Title: Engineered single chain antibody fragments for radioimmunotherapy.
Location: Italy
Keywords: Animals, Antibodies, Monoclonal, Antibody Formation, Drug Design, Humans, Immunoglobulin Fragments, Protein Engineering, Radioimmunotherapy
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/474
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