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Engineering antibodies for clinical applications in cancer

Chester, K; Pedley, B; Tolner, B; Violet, J; Mayer, A; Sharma, S; Boxer, G; ... Begent, R; + view all (2004) Engineering antibodies for clinical applications in cancer. Tumor Biology , 25 (1-2) pp. 91-98.

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Abstract

The 'magic bullet' concept predicted over a century ago that antibodies would be used to target cancer therapy. Since then initial problems that were related to specificity, purity and immungenicity of antibody-based reagents have slowly been overcome due to developments in technology and increased knowledge. As a result, antibodies are in use for many clinical applications and now comprise the second largest category of medicines in clinical development after vaccines. For antibody- based cancer therapeutics the last 20 years have met with an explosion of knowledge about the biology of the disease and potential targets as well as new technology which allows cloning and manipulation of multifunctional antibody-based molecules. However, the focus still remains on developing therapeutics that will have potential for treating cancer in people and this is efficiently assessed in mechanistic clinical trials that feed back to the laboratory for further development. This review illustrates the mechanistic approach to making new molecules for antibody imaging and therapy of cancer. It is illustrated by examples of radioimmunotherapy and antibody-directed enzyme prodrug therapy developed by the authors. Copyright (C) 2004 S. Karger AG, Basel

Type: Article
Title: Engineering antibodies for clinical applications in cancer
Additional information: WoS ID: 000221941500012 JournalEnglishReview36KARGERBAGSHAWE KD, 1988, BRIT J CANCER, V58, P700; BAGSHAWE KD, 1995, MOL MED TODAY, V1, P424; BEGENT RHJ, 1989, BRIT J CANCER, V60, P406; BEGENT RHJ, 1996, NAT MED, V2, P979; BHATIA J, 2000, INT J CANCER, V85, P571; BOEHM MK, 2000, BIOCHEM J 2, V346, P519; BOEHM MK, 2000, FEBS LETT, V475, P11; BOXER G, 1999, BRIT J CANCER, V80, P922; CARTER P, 2001, NAT REV CANCER, V1, P118; CASEY JL, 1995, J IMMUNOL METHODS, V179, P105; CHESTER KA, 1994, LANCET, V343, P455; CURRIE GA, 1972, BRIT J CANCER, V26, P141; EAST L, 2002, BBA-GEN SUBJECTS, V1572, P364; FLYNN AA, 2002, INT J RADIAT BIOL, V78, P407; FRANCIS RJ, 2002, BRIT J CANCER, V87, P600; FRANCIS RJ, IN PRESS EUR J NUCL; FRASER IP, 1998, SEMIN IMMUNOL, V10, P363; GLENNIE MJ, 2003, DRUG DISCOV TODAY, V8, P503; GORDON S, 2002, CELL, V111, P927; HERICOURT J, 1895, CR HEBD ACAD SCI, V121, P567; HUDSON PJ, 2003, NAT MED, V9, P129; HUSTON JS, 1993, INT REV IMMUNOL, V10, P195; LANE DM, 1994, BRIT J CANCER, V70, P521; LEE YC, 2002, J MOL BIOL, V320, P107; MACH JP, 1983, CANCER RES, V43, P5593; MAYER A, 2000, CLIN CANCER RES, V6, P1711; MCCAFFERTY J, 1990, NATURE, V348, P552; MEDZIHRADSZKY KF, 2004, GLYCOBIOLOGY, V14, P27; MICHAEL NP, 1996, IMMUNOTECHNOLOGY, V2, P47; NAGL SB, 2002, CURR DRUG TARGETS, V3, P387; NAPIER MP, 2000, CLIN CANCER RES, V6, P765; PEDLEY RB, 2001, CANCER RES, V61, P4716; PEDLEY RB, 2002, INT J RADIAT ONCOL, V54, P1524; SPENCER DIR, 2002, PROTEOMICS, V2, P271; VONBEHRING E, 1961, MILESTONES MICROBIOL, P138; WINTER G, 1991, NATURE, V349, P2930827ZFBASELChester K Univ Coll London, Royal Free & Univ Coll Med Sch, Dept Oncol, Rowland Hill St, London NW3 2PF, EnglandTUMOR BIOLALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
Keywords: ANTIBODY, antibody-directed enzyme rodrug therapy, CANCER, carcinoembryonic antigen, CHAIN FV ANTIBODY, clinical trials, CLINICAL-APPLICATIONS, COLORECTAL-CARCINOMA, DISEASE, EFFICACY, ENZYME PRODRUG THERAPY, FUSION PROTEIN, MANNOSE RECEPTOR, MFE-23, PRODRUG THERAPY, radioimmunotherapy, SINGLE-CHAIN FV, THERAPY, TRIAL, TRIALS, TUMOR
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/470
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