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Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN

Mallick, AI; Parvizi, P; Read, LR; Nagy, E; Behboudi, S; Sharif, S; (2011) Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN. VACCINE , 29 (8) 1657 - 1665. 10.1016/j.vaccine.2010.12.046.

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Abstract

Influenza virosomes are virus-like particles, representing a platform for vaccine development. In this study, we examined the immunogenicity of avian influenza virosomes with or without inclusion of recombinant chicken interferon-gamma (rChIEN-gamma) or CpG-ODN in chickens. Immunization with virosomes adjuvanted with CpG-ODN elicited the highest haemagglutination inhibition antibody titres, as well as IgG and IgA serum antibody responses. Moreover, Virosomes +CpG-ODN formulation induced an antigen-specific spleen cell proliferation and IFN-gamma expression. In conclusion, our results demonstrated that virus-specific antibody- and cell-mediated responses may be induced in chickens immunized with virosomes and these responses can be enhanced by incorporating CpG-ODN in the virosome vaccine formulation. (C) 2011 Elsevier Ltd. All rights reserved.

Type:Article
Title:Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN
DOI:10.1016/j.vaccine.2010.12.046
Keywords:Virosomes, Chicken, Immune response, Interferon gamma, Antibody, Influenza virus, H4N6, CpG-ODN, NEWCASTLE-DISEASE VIRUS, T-LYMPHOCYTE ACTIVITY, INTERFERON-GAMMA, IN-VIVO, PROTECTIVE IMMUNITY, PROTEIN ANTIGENS, CELL RESPONSES, LIVER-CELLS, LIPOSOMES, HEMAGGLUTININ
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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