Trends in the management of hepatitis B virus infection after liver transplantation.
Annals of Gastroenterology
Post-transplant hepatitis B virus (HBV) recurrence occurs in the majority of patients transplanted for HBV liver disease, if left untreated. Post-transplant prophylaxis with hepatitis B immune globulin (HBIG) has significantly reduced HBV recurrence rates, but it is rather ineffective in patients with chronic liver disease and pre-transplant detectable serun HBV-DNA by hybridization assays. Moreover, long-term HBIG administration increases the cost of post-transplant medical therapy and may be associated with emergence of escape HBV mutants. Lamivudine is the first antiviral patients. Pre-transplant lamivudine therapy lowers HBV viremia, decreasing the risk of post-transplant HBV recurrence, but to try and minimize virologic break-throughs due to resistant HBV strains, it should be started within the prior to 6 months the anticipated timing of transplantation, which is often difficult in practice. Prophylactic post-transplant lamivudine monotherapy is associated with progressively increasing HBV recurrence rates, but combined therapy with lamivudine and HBIG at relatively low dosage is currently the most effective approach in this setting, even in HBV-DNA positive patients, who also receive lamivudine in the pre-transplant period. The most frequent therapy for post-transplant HBV recurrence is lamivudine, but the increasing resistance rates represent a challenging problem. Adefovir dipivoxil is currently the most promising agent amongst those tried for lamivudine resistant HBV strains. All these advances in anti-HBV therapy have made HBV liver disease and indication for liver transplantation, irrespective of viral replication status, a complete turn around from 10 years ago.
|Title:||Trends in the management of hepatitis B virus infection after liver transplantation|
|Open access status:||An open access publication|
|Keywords:||Adefovir, Entecavir, Hepatitis B immune globulin, Hepatitis B virus, Lamivudine, Liver transplantation, Nucleoside analogues, Viral resistance, YMDD mutants|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
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