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Ulcerative colitis complicated by Budd-Chiari syndrome and primary sclerosing cholangitis

Karatapanis, ST; McCormick, PA; Burroughs, AK; (1992) Ulcerative colitis complicated by Budd-Chiari syndrome and primary sclerosing cholangitis. European Journal of Gastroenterology and Hepatology , 4 (8) 683 - 686.

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Abstract

Objective: Hepatic vein thrombosis (Budd-Chiari syndrome) has rarely been associated with ulcerative colitis and never with primary sclerosing cholangitis. Design: A single patient case report describing the course of such a patient, with a brief review of the literature. Setting: Hepatobiliary unit in a university hospital. Patient: A 49-year-old man with a 15-year history of mild ulcerative colitis presented with a subacute onset of Budd-Chiari syndrome. Primary sclerosing cholangitis was suspected because of a high serum alkaline phosphatase and confirmed at autopsy. Interventions: The patient received conservative treatment. Outcome: The patient died. Conclusions: Although causal relationship between hepatic vein thrombosis and inflammatory bowel disease is controversial, recent evidence has shown that active and extensive bowel disease may lead to a hypercoagulable state predisposing to the development of the Budd-Chiari syndrome.

Type:Article
Title:Ulcerative colitis complicated by Budd-Chiari syndrome and primary sclerosing cholangitis

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