Jie, X; Rodriguez, B; Trayanova, N; (2005) The ischemic heart: what causes ectopic beating? Conf Proc IEEE Eng Med Biol Soc , 7 7194 - 7197. 10.1109/IEMBS.2005.1616168.
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The mechanisms by which spontaneous electrical activity originates in the ischemic heart and leads to arrhythmia remain unknown, however mechanical stretch of the diseased region has been hypothesized to play a role. The goal of this study is to investigate the conditions that favor the initiation of stretch-induced premature beats in the ischemic heart. We employ a mathematical model of the ischemic cell subjected to stretch. The study found that upon stretch, spontaneous beats occur in the ischemic cell, which are due to the stretch-induced re-activation of the L-type calcium current.
|Title:||The ischemic heart: what causes ectopic beating?|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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