Cox, BT; Arridge, SR; Kostli, KP; Beard, PC; (2005) Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution. In: Oraevsky, AA and Wang, LV, (eds.) **Photons Plus Ultrasound: Imaging and Sensing 2005.** (pp. 49 - 55). SPIE-INT SOC OPTICAL ENGINEERING

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## Abstract

Photoacoustic imaging, which generates a map of the initial acoustic pressure distribution generated by a short laser pulse, has been demonstrated by several authors. Quantitative photoacoustic imaging takes this one stage further to produce a map of the distribution of an optical property of the tissue, in this case absorption, which can then be related to a physiological parameter. In this technique, the initial pressure distribution is assumed to be proportional to the absorbed laser energy density. A model of light transport in scattering media is then used to estimate the distribution of optical properties that would result in such a pattern of absorbed energy. The light model used a finite element implementation of the diffusion equation (with the delta-E(3) approximation included to improve the accuracy at short distances inside the scattering medium). An algorithm which applies this model iteratively and converges on a quantitative estimate of the optical absorption distribution is described. 2D examples using simulated data (initial pressure maps) with and without noise are shown to converge quickly and accurately.

Type: | Proceedings paper |
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Title: | Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution |

Event: | 6th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-Optics |

Location: | San Jose, CA |

Dates: | 2005-01-23 - 2005-01-25 |

ISBN: | 0-8194-5671-3 |

DOI: | 10.1117/12.597190 |

Keywords: | photoacoustic, quantitative imaging, optical absorption coefficient, RECONSTRUCTION, TOMOGRAPHY |

UCL classification: | UCL > School of BEAMS > Faculty of Engineering Science > Computer Science UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering |

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