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Effects of STN DBS on memory guided force control in Parkinson's disease (June 2007)

Prodoehl, J; Corcos, DM; Rothwell, JC; Metman, LV; Bakay, RAE; Vaillancourt, DE; (2007) Effects of STN DBS on memory guided force control in Parkinson's disease (June 2007). IEEE T NEUR SYS REH , 15 (2) 155 - 165. 10.1109/TNSRE.2007.896992.

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Abstract

This study examined the control of elbow force in nine patients with Parkinson's disease when visual feedback was available and when visual feedback was removed to determine how medication (Meds) and unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) affect memory guided force control. Patients were examined in each of four treatment conditions: 1) off treatment; 2) Meds; 3) STN DBS; and 4) Meds plus STN DBS. With visual feedback available, there was no difference in force output across treatment conditions. When visual feedback was removed force output drifted under the target in both the off-treatment and the Meds conditions. However, when on STN DBS or Meds plus STN DBS force output drifted above the target. As such, only STN DBS had a significant effect on force output in the vision removed condition. Increased force output when on STN DBS may have occurred due to disruptions in the basal ganglia-thalamo-cortical circuitry. We suggest that modulation of output of the internal segment of the globus pallidus by STN DBS may drive the effect of STN DBS on memory guided force control.

Type: Article
Title: Effects of STN DBS on memory guided force control in Parkinson's disease (June 2007)
DOI: 10.1109/TNSRE.2007.896992
Keywords: deep brain stimulation (DBS), force, globus pallidus, motor memory, vision, DEEP-BRAIN-STIMULATION, SUBTHALAMIC NUCLEUS STIMULATION, GLOBUS-PALLIDUS, BASAL-GANGLIA, REACTION-TIME, BILATERAL STIMULATION, CLINICAL-DIAGNOSIS, MOVEMENT-DISORDERS, FUNCTIONAL-ANATOMY, FIRING PATTERN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/44216
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