Hosking, CR; Fausto, U; Hogan, C; Ferber, E; Figueroa, A; Gevaert, K; ... Fujita, Y; + view all Hosking, CR; Fausto, U; Hogan, C; Ferber, E; Figueroa, A; Gevaert, K; Birchmeier, W; Briscoe, J; Fujita, Y; - view fewer (2007) The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Molecular Biology of the Cell , 18 1918 - 1927. 10.1091/mbc.E06-10-0941.
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In epithelial cells, p120 catenin localizes at cell-cell contacts and regulates adhesive function of the cadherin complex. In addition, p120 has been reported to localize in the nucleus, although the nuclear function of p120 is not fully understood. Here, we report the identification of Glis2 as a novel binding protein for p120. Glis2 is a Krüppel-like transcriptional repressor with homology to the Gli family, but its physiological function has not been well characterized. In this study we show that co-expression of Glis2 and Src induces nuclear translocation of p120. Furthermore, p120 induces the C-terminal cleavage of Glis2, and this cleavage is further enhanced by Src. The cleaved form of Glis2 loses one of its five zinc finger domains, but is still able to bind DNA. Functional studies in chick neural tube indicate that full-length Glis2 can affect neuronal differentiation, while the cleaved form requires co-expression of p120 to have a similar effect. These data indicate that p120 has additional novel functions in the nucleus together with Glis2.
|Title:||The transcriptional repressor Glis2 is a novel binding partner for p120 catenin|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > MRC/UCL Lab for Molecular Cell Biology|
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