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Antiangiogenic gene therapy for cancer treatment.

Davidoff, AM; Nathwani, AC; (2004) Antiangiogenic gene therapy for cancer treatment. Curr Hematol Rep , 3 (4) pp. 267-273.

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Abstract

It is now well established that tumor growth and spread are angiogenesis-dependent processes. Therefore, inhibition of angiogenesis is likely to be an effective anticancer approach. A gene therapy-mediated approach to the delivery of antiangiogenic agents has several advantages, including the potential for sustained expression. However, several variables need to be considered when designing this approach. In addition to the choice of angiogenesis inhibitor, these approaches include the system for gene transfer and the target for gene delivery/site of inhibitor expression. This review summarizes the major alternatives within each of these categories and provides illustrative examples of their use in preclinical models.

Type: Article
Title: Antiangiogenic gene therapy for cancer treatment.
Location: United States
Keywords: Angiogenesis Inhibitors, Drug Delivery Systems, Genetic Therapy, Genetic Vectors, Humans, Neoplasms
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/42371
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