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Long-lasting effects of high frequency repetitive transcranial magnetic stimulation in major depressed patients

Bortolomasi, M; Minelli, A; Fuggetta, G; Perini, M; Comencini, S; Fiaschi, A; Manganotti, P; (2007) Long-lasting effects of high frequency repetitive transcranial magnetic stimulation in major depressed patients. Psychiatry Research , 150 (2) 181 - 186.

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Abstract

The majority of previous clinical studies have indicated that repetitive transcranial magnetic stimulation (rTMS) may haveantidepressant effects. Herein, we investigated the longitudinal, long-term antidepressant efficacy of daily left prefrontal cortex (PFC) rTMS for a 1-week period. Nineteen patients were randomly assigned to two treatment groups at 90% of individual motor threshold (MT): Twelve received active repetitive transcranial magnetic stimulation and seven received sham treatment. Each patient underwent five sessions of twenty 2-s trains of 20 Hz rTMS with 800 stimuli/day. The Beck Depression Inventory andthe Hamilton Depression Rating Scale were used to assess severity of depression at 1, 4 and 12 weeks post-therapy. Asignificant reduction of baseline depression scores was observed after 1 week of active treatment that lasted for 1 month, indicating improvement of depressive symptoms. No significant effects were observed in patients receiving sham treatment. The results of this controlled study are in agreement with the findings of previous studies suggesting that daily left PFC rTMS has an antidepressant effect.

Type:Article
Title:Long-lasting effects of high frequency repetitive transcranial magnetic stimulation in major depressed patients
Additional information:Imported via OAI, 7:29:00 4th Aug 2007
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Life Sciences

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