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Fourier Transform Infrared Spectroscopic Analysis of Breast Cancer Tissues; Identifying Differences between Normal Breast, Invasive Ductal Carcinoma, and Ductal Carcinoma In Situ of the Breast

Rehman, S; Movasaghi, Z; Darr, JA; Rehman, IU; (2010) Fourier Transform Infrared Spectroscopic Analysis of Breast Cancer Tissues; Identifying Differences between Normal Breast, Invasive Ductal Carcinoma, and Ductal Carcinoma In Situ of the Breast. APPL SPECTROSC REV , 45 (5) 355 - 368. 10.1080/05704928.2010.483674.

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Abstract

A nondestructive method employing Fourier transform infrared (FTIR) microspectroscopy coupled with attenuated total reflectance (ATR) objective for the analysis of histopathological specimens is described. Malignant breast tissue specimens have been analyzed to demonstrate the hypothesis that chemical changes taking place in biological tissue can be reliably and reproducibly identified. This study is the first report to elucidate clear spectral differences between different ductal carcinoma in situ (DCIS) grades. Sixty individual cases of breast carcinoma including DCIS and invasive ductal carcinoma (IDC) and seven cases of normal breast tissues were studied using the FTIR-ATR spectroscopic technique. FTIR analysis of tissue sections has provided distinct spectra that can be used to distinguish between the nuclear grades of DCIS and IDC of the breast. It was concluded that FTIR could objectively and reproducibly discriminate between DCIS and IDC grades without sample destruction. In the future, applications of FTIR approaches should become feasible in the nondestructive express classification of grades and diagnosis of breast carcinoma.

Type:Article
Title:Fourier Transform Infrared Spectroscopic Analysis of Breast Cancer Tissues; Identifying Differences between Normal Breast, Invasive Ductal Carcinoma, and Ductal Carcinoma In Situ of the Breast
DOI:10.1080/05704928.2010.483674
Keywords:FTIR-ATR spectroscopy, breast carcinoma, invasive ductal carcinoma (IDC), ductal carcinoma in situ (DCIS), breast cancer, RAMAN-SPECTROSCOPY, FTIR SPECTROSCOPY, BIOLOGICAL TISSUES, PROGNOSTIC FACTORS, LUNG TISSUES, SPECTRA, MICROSPECTROSCOPY, CELLS, CLASSIFICATION, EPIDEMIOLOGY
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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