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DURATIONS OF COMPLETE FOCAL MUCOSAL ISCHEMIA NEEDED TO PRODUCE GASTRIC-ULCERATION

PIASECKI, CK; THRASIVOULOU, C; (1992) DURATIONS OF COMPLETE FOCAL MUCOSAL ISCHEMIA NEEDED TO PRODUCE GASTRIC-ULCERATION. EUR J GASTROEN HEPAT , 4 (6) 487 - 493.

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Abstract

Objective: We have shown that in man some individuals have end-arteries which are found only in the ulcer-bearing areas, suggesting that compression of such vessels by spasm of external muscle or muscularis mucosae could cause ulceration. In a guinea-pig model, permanent ligation of a single intramural mucosal end-artery produced focal mucosal ulceration. We therefore used this model to study what durations of temporary obstruction were required to produce ulceration.Design: Based on our experience that in the guinea-pig mucosal arteries are end-arteries and that spasm of muscle layer completely occludes flow in an artery passing through that layer, we mimicked spasm ot muscularis mucosae by occluding a single mucosal end-artery with a snare.Methods: Each animal received either a single obstruction to an individual mucosal end-artery for 20, 30 or 40 min, or repeated obstructions of one artery each lasting 1, 5 or 10 min. Following 3 h of recovery the stomach was removed and the mucosa examined histologically for signs of necrosis.Results: Mucosal necrosis began to occur following a single 30-min occlusion or after four 5-min occlusions. There was no necrosis in sham procedures.Conclusion: Either a single obstruction of a mucosal end-artery lasting 30-min, or four 5-min successive obstructions suffice to initiate mucosal ulceration. The relevance of this to the possibility that ulceration may be caused by focal spasm of muscularis mucosae or muscularis externa is discussed.

Type: Article
Title: DURATIONS OF COMPLETE FOCAL MUCOSAL ISCHEMIA NEEDED TO PRODUCE GASTRIC-ULCERATION
Keywords: PEPTIC ULCER, ACUTE ULCERATION, THROMBOSIS, ETIOLOGY OF GASTRODUODENAL AND ACUTE ULCERATION, ISCHEMIA
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/408692
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