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The use of pharmacokinetics to improve the treatment of ovarian cancer: combination paclitaxel (Taxol(R))carboplatin

Calvert, AH; (1997) The use of pharmacokinetics to improve the treatment of ovarian cancer: combination paclitaxel (Taxol(R))carboplatin. INT J GYNECOL CANCER , 7 14 - 17.

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Abstract

On confirming that paclitaxel (Taxol(R), Bristol-Myers Squibb Company)cisplatin is effective in treating advanced ovarian cancer, investigations have turned toward reducing the toxicity observed with the regimen. Replacement of cisplatin with its analogue carboplatin would be expected to result in comparable response rates but less neuropathy and nephrotoxicity and fewer of cisplatin's other toxic effects as well. Some studies suggest, however, that combination paclitaxel-carboplatin is associated with pharmacokinetic interactions that result in lower-than-expected areas under the plasma concentration-time curve of carboplatin. However, our own studies suggest that such variations are probably attributable to methodologic differences in estimating glomerular filtration rates, leading to underdosing of carboplatin. It is concluded that paclitaxel-carboplatin can be combined in a variety of regimens without compromising the dose of either agent.

Type: Article
Title: The use of pharmacokinetics to improve the treatment of ovarian cancer: combination paclitaxel (Taxol(R))carboplatin
Keywords: ovarian cancer, paclitaxel-carboplatin, pharmacokinetics, PHASE-I TRIAL, CELL LUNG-CANCER, EVERY 21 DAYS, CREATININE CLEARANCE, RENAL-FUNCTION, TAXOL, CARBOPLATIN, INFUSION, PREDICTION, CARCINOMA
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/408418
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