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High resolution Ca/P maps of bone architecture

Tzaphlidou, M; Speller, R; Royle, G; Griffiths, J; (2004) High resolution Ca/P maps of bone architecture. In: Seibert, JA, (ed.) 2004 IEEE Nuclear Science Symposium Conference Record, Vols 1-7. (pp. 3267 - 3270). IEEE

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Abstract

The Ca/P ratio was measured in cortical bone samples from the femoral neck, front and rear tibia of female rats (1.5 yr of age), using synchrotron radiation microtomography. Use of a monoenergetic x-ray beam, as provided by the synchrotron facility, generates accurate 3-D maps of the linear attenuation coefficient within the sample and hence gives the ability to map different chemical components. MicroC`T data sets were collected at 20 and 28 keV for each bone sample and two calibration phantoms. From the 3-D data sets, multiple 2-D slices were reconstructed with a slice thickness of similar to 14 mu m. Regions of interest were defined around suitable sites and were converted to Ca/P ratios using the data collected from the test phantoms. Mean values (M+SD) for cortical femoral, front and rear tibias are: 2.12+0.08, 1.75+0.06 and 1.94+0.07 respectively. Differences between the same bone sites from different animals are not significant (0.3 < p < 0.5) while those between different bone sites are highly significant (p < 10(-3)). Differences between estimates made at 20 and 28 keV are not significant (p > 0.5).

Type:Proceedings paper
Title:High resolution Ca/P maps of bone architecture
Event:Nuclear Science Symposium/Medical Imaging Conference
Location:Rome, ITALY
Dates:2004-10-16 - 2004-10-22
ISBN:0-7803-8700-7
Keywords:SYNCHROTRON-RADIATION MICROTOMOGRAPHY, NEUTRON-ACTIVATION ANALYSIS, CALCIUM-PHOSPHORUS RATIO, X-RAY MICROTOMOGRAPHY, HUMAN FEMORAL-NECK, CALCIUM/PHOSPHORUS RATIO, MINERAL-CONTENT, CORTICAL BONE, TRABECULAR BONE, HEALTHY HUMANS
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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