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Impedance changes during the compound nerve action potential: implications for impedance imaging of neuronal depolarisation in the brain.

Holder, DS; (1992) Impedance changes during the compound nerve action potential: implications for impedance imaging of neuronal depolarisation in the brain. Med Biol Eng Comput , 30 (2) pp. 140-146.

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Abstract

Impedance changes were measured during the compound action potential (CAP) in isolated crab nerves with 50 kHz or direct applied current (DC), to suggest an optimal frequency for the imaging of neuronal depolarisation by electrical impedance tomography (EIT). With DC, a predominant apparent impedance decrease of 0.2-0.7 per cent of the resting baseline was observed, which had a time course similar to that of the action potential. Control recordings suggested that these changes could not be attributed to technical errors resulting from the measurement method. A component in some measurements was attributable to effects of the measuring current on the latency of the CAP, but the mechanism underlying the remainder of the changes was unclear. No changes greater than +/- 0.005 per cent were seen with measurement at 50 kHz. This suggests that research into noninvasive rapid imaging of nervous activity in the brain with EIT would be more profitably performed with measurements at frequencies lower than the 50 kHz currently used for safety reasons.

Type: Article
Title: Impedance changes during the compound nerve action potential: implications for impedance imaging of neuronal depolarisation in the brain.
Location: United States
Keywords: Action Potentials, Animals, Brachyura, Electric Impedance, Nervous System Physiological Phenomena, Tomography
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/39197
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