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Effects of urethane, alphaxolone/alphadolone, or halothane with or without neuromuscular blockade on survival during repeated episodes of global cerebral ischaemia in the rat.

Holder, DS; (1992) Effects of urethane, alphaxolone/alphadolone, or halothane with or without neuromuscular blockade on survival during repeated episodes of global cerebral ischaemia in the rat. Lab Anim , 26 (2) pp. 107-113. 10.1258/002367792780745814.

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Abstract

The effect of 4 anaesthetic regimens on blood pressure and survival was investigated during repeated episodes of cerebral ischaemia in the rat induced by diathermy of the vertebral arteries and reversible occlusion of the carotid arteries. The best results were obtained with inspired halothane with neuromuscular blockade and artificial ventilation, followed in order by halothane, intravenous alphaxolone/alphadolone, and intraperitoneal urethane with spontaneous ventilation.

Type: Article
Title: Effects of urethane, alphaxolone/alphadolone, or halothane with or without neuromuscular blockade on survival during repeated episodes of global cerebral ischaemia in the rat.
Location: England
DOI: 10.1258/002367792780745814
Keywords: Anesthetics, Animals, Arterial Occlusive Diseases, Brain Ischemia, Carotid Artery Diseases, Disease Models, Animal, Drug Combinations, Halothane, Male, Neuromuscular Blocking Agents, Pregnanediones, Rats, Rats, Inbred Strains, Respiration, Artificial, Retrospective Studies, Urethane
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/39196
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