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Simulation of cardiac pathologies using an electromechanical biventricular model and XMR interventional imaging

Sermesant, M; Rhode, K; Sanchez-Ortiz, GI; Camara, O; Andriantsimiavona, R; Hegde, S; Rueckert, D; ... Razavi, R; + view all (2005) Simulation of cardiac pathologies using an electromechanical biventricular model and XMR interventional imaging. MEDICAL IMAGE ANALYSIS , 9 (5) 467 - 480. 10.1016/j.media.2005.05.003.

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Abstract

Simulating cardiac electromechanical activity is of great interest for a better understanding of pathologies and for therapy planning. Design and validation of such models is difficult due to the lack of clinical data. XMR systems are a new type of interventional facility in which patients can be rapidly transferred between X-ray and MR systems. Our goal is to design and validate an electromechanical model of the myocardium using XMR imaging. The proposed model is computationally fast and uses clinically observable parameters. We present the integration of anatomy, electrophysiology, and motion from patient data. Pathologies are introduced in the model and simulations are compared to measured data. Initial qualitative comparison on the two clinical cases presented is encouraging. Once fully validated, these models will make it possible to simulate different interventional strategies. (c) 2005 Elsevier B.V. All rights reserved.

Type: Article
Title: Simulation of cardiac pathologies using an electromechanical biventricular model and XMR interventional imaging
Location: St Malo, FRANCE
DOI: 10.1016/j.media.2005.05.003
Keywords: data fusion, patient-specific model, electrophysiology study, electromechanical coupling, interventional imaging, cardiac pathologies, RADIOFREQUENCY CATHETER ABLATION, MULTIELECTRODE BASKET CATHETER, CONGENITAL HEART-DISEASE, MR-IMAGES, REGISTRATION, TACHYCARDIA, ARRHYTHMIAS, CHILDREN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/38230
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