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Mechanical signals, IGF-I gene splicing, and muscle adaptation

Goldspink, G; (2005) Mechanical signals, IGF-I gene splicing, and muscle adaptation. PHYSIOLOGY , 20 232 - 238.

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Abstract

Combining physiological and molecular biology methods made it possible to identify and characterize a local muscle growth/repair factor (MGF). Following resistance exercise, MGF "kick starts" muscle hypertrophy and is important in local tissue repair. Loss of muscle mass in old age and certain diseases is associated with an impaired ability to express MGF.

Type:Article
Title:Mechanical signals, IGF-I gene splicing, and muscle adaptation
Keywords:SKELETAL-MUSCLE, GROWTH-FACTOR, RESISTANCE EXERCISE, TRANSGENIC MICE, SATELLITE CELL, EXPRESSION, REGENERATION, DIFFERENTIATION, ISOFORM, HYPERTROPHY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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