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Extending CATH: increasing coverage of the protein structure universe and linking structure with function

Cuff, AL; Sillitoe, I; Lewis, T; Clegg, AB; Rentzsch, R; Furnham, N; Pellegrini-Calace, M; ... Orengo, CA; + view all (2011) Extending CATH: increasing coverage of the protein structure universe and linking structure with function. NUCLEIC ACIDS RES , 39 D420 - D426. 10.1093/nar/gkq1001. Gold open access

Abstract

CATH version 3.3 (class, architecture, topology, homology) contains 128 688 domains, 2386 homologous superfamilies and 1233 fold groups, and reflects a major focus on classifying structural genomics (SG) structures and transmembrane proteins, both of which are likely to add structural novelty to the database and therefore increase the coverage of protein fold space within CATH. For CATH version 3.4 we have significantly improved the presentation of sequence information and associated functional information for CATH superfamilies. The CATH superfamily pages now reflect both the functional and structural diversity within the superfamily and include structural alignments of close and distant relatives within the superfamily, annotated with functional information and details of conserved residues. A significantly more efficient search function for CATH has been established by implementing the search server Solr (http://lucene.apache.org/solr/). The CATH v3.4 webpages have been built using the Catalyst web framework.

Type: Article
Title: Extending CATH: increasing coverage of the protein structure universe and linking structure with function
Open access status: An open access publication
DOI: 10.1093/nar/gkq1001
Keywords: DOMAIN-STRUCTURE DATABASE, STRUCTURE ALIGNMENT, CLASSIFICATION, GENOMICS, ANNOTATION, SUPERFAMILIES, DIVERGENCE, RESOURCE, GENE3D, IMPACT
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Structural and Molecular Biology
UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Engineering Science
URI: http://discovery.ucl.ac.uk/id/eprint/374996
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