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Photodynamic therapy for locally advanced pancreatic cancer: early clinical results

Sandanayake, NS; Huggett, MT; Bown, SG; Pogue, BW; Hasan, T; Pereira, SP; (2010) Photodynamic therapy for locally advanced pancreatic cancer: early clinical results. In: Kessel, DH, (ed.) OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XIX. (pp. ? - ?). SPIE-INT SOC OPTICAL ENGINEERING

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Abstract

Pancreatic adenocarcinoma ranks as the fourth most common cause of cancer death in the USA. Patients usually present late with advanced disease, limiting attempted curative surgery to 10% of cases. Overall prognosis is poor with one-year survival rates of less than 10% with palliative chemotherapy and/or radiotherapy. Given these dismal results, a minimally invasive treatment capable of local destruction of tumor tissue with low morbidity may have a place in the treatment of this disease. In this paper we review the preclinical photodynamic therapy (PDT) studies which have shown that it is possible to achieve a zone of necrosis in normal pancreas and implanted tumour tissue. Side effects of treatment and evidence of a potential survival advantage are discussed. We describe the only published clinical study of pancreatic interstitial PDT, which was carried out by our group (Bown et al Gut 2002), in 16 patients with unresectable locally advanced pancreatic adenocarcinoma. All patients had evidence of tumor necrosis on follow-up imaging, with a median survival from diagnosis of 12.5 months. Finally, we outline a phase I dose-escalation study of verteporfin single fibre PDT followed by standard gemcitabine chemotherapy which our group is currently undertaking in patients with locally advanced pancreatic cancer. Randomized controlled studies are also planned.

Type: Proceedings paper
Title: Photodynamic therapy for locally advanced pancreatic cancer: early clinical results
Event: Conference on Optical Methods for Tumor Treatment and Detection - Mechanisms and Techniques in Photodynamic Therapy XIX
Location: San Francisco, CA
Dates: 2010-01-23 - 2010-01-25
ISBN-13: 978-0-8194-7947-1
DOI: 10.1117/12.846555
Keywords: Photodynamic therapy, verteporfin, pancreatic cancer, pancreatic adenocarcinoma, SYRIAN GOLDEN-HAMSTER, ADJACENT TISSUES, VERTEPORFIN, GEMCITABINE, STATISTICS, MANAGEMENT, CARCINOMA, DAMAGE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/374951
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