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Outbreaks of infectious diseases in stem cell transplant units: a silent cause of death for patients and transplant programmes

McCann, S; Byrne, JL; Rovira, M; Shaw, P; Ribaud, P; Sica, S; Volin, L; ... Cordonnier, C; + view all (2004) Outbreaks of infectious diseases in stem cell transplant units: a silent cause of death for patients and transplant programmes. BONE MARROW TRANSPLANTATION , 33 (5) pp. 519-529.

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Abstract

Following the closure of the National Blood and Bone Marrow Transplant Unit in Dublin, because of an outbreak of vancomycin-resistant enterococcal infection, a survey was carried out by the EBMT to investigate the occurrence of outbreaks of infection in SCT units and the impact on patient morbidity, mortality and the administration of the transplant programme over a 10-year period from 1991 to 2001. A total of 13 centres reported 23 outbreaks of infection involving 231 patients: 10 bacterial, eight viral and five fungal outbreaks were reported and 56 deaths were attributed to infection. All fungal and bacterial deaths and the majority of viral deaths occurred in allograft recipients. In all outbreaks, the infection was reported to be hospital acquired and in all the viral, and half the bacterial infections, cross-infection was a major factor. All viral, four of 10 bacterial and three of five fungal outbreaks occurred in HEPA filtered rooms. A total of 12 SCT units reported a partial or total closure. The introduction of mandatory quality management systems such as JACIE should result in a change in attitude to 'incident reporting' and together with future surveys should reduce the incidence of infectious outbreaks in SCT units

Type: Article
Title: Outbreaks of infectious diseases in stem cell transplant units: a silent cause of death for patients and transplant programmes
Additional information: Language: EnglishDocument status: MedlineDataStar source field: Bone marrow transplantation, {Bone-Marrow-Transplant}, Mar 2004, vol. 33, no. 5, p. 519-29, ISSN: 0268-3369DataStar update date: 20050101
Keywords: Aspergillosis, blood, Bone Marrow Transplantation, Cross Infection, Data Collection, Disease Outbreaks, Enterococcus faecalis, epidemiology, Filtration, Gram-Positive Bacterial Infections, Humans, Incidence, Ireland, Laboratories, mortality, Paramyxoviridae Infections, Pseudomonas Infections, Questionnaires, Respiratory Syncytial Virus Infections, Serratia Infections, statistics & numerical data, BLOOD, BONE, bone marrow transplantation, BONE-MARROW, bone-marrow-transplantation, CELL, death, DISEASE, hospital, IMPACT, incidence, infection, IRELAND, language, MANAGEMENT, MEDLINE, morbidity, patient, Patients, recipient, RECIPIENTS, SYSTEM, TRANSPLANTATION, viral
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/37154
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