UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages

Boven, L; van, M; Boot, R; Mehta, A; Boon, L; Aerts, J; Laman, J; (2004) Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages. AMERICAN JOURNAL OF CLINICAL PATHOLOGY , 122 (3) pp. 359-369.

Full text not available from this repository.

Abstract

Although the existence of anti-inflammatory alternatively activated macrophages (aamphi) has been accepted widely based on in vitro studies, their in vivo location, phenotype, and function still are debated. Gaucher disease (GD) is caused by a genetic deficiency in the lysosomal enzyme glucocerebrosidase and is characterized by accumulation of glycosphingolipids in so-called Gaucher cells (GCs). By using immunohistochemical analysis, we investigated whether this results in an aamphi phenotype. GCs are macrophage-like cells, expressing acid phosphatase, CD68, CD14, and HLA class II, but not CD11b, CD40, or dendritic cell markers. GCs show infrequent immunoreactivity for mannose receptor GCs did not express proinflammatory cytokines such as tumor necrosis factor alpha and monocyte chemoattractant protein 1, but did express the aamphi markers CD163, CCL18, and interleukin-1 receptor antagonist. Furthermore, CD36 and signal receptor protein alpha, involved in lipid uptake, also were observed on GCs. Thus, GCs represent a distinctive population of myeloid cells that resemble aamphi but differ from previously described in vitro aamphi

Type: Article
Title: Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages
Additional information: Language: EnglishDocument status: MedlineDataStar source field: American journal of clinical pathology, {Am-J-Clin-Pathol}, Sep 2004, vol. 122, no. 3, p. 359-69, ISSN: 0002-9173DataStar update date: 20050101
Keywords: CELL, CELLS, cytokine, DISEASE, IN-VITRO, language, MEDLINE, NECROSIS, population, protein, receptor, VITRO
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/37148
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item