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Carboxyhemoglobin levels in Kenyan children with Plasmodium falciparum malaria

Cunnington, AJ; Kendrick, SF; Wamola, B; Lowe, B; Newton, CR; (2004) Carboxyhemoglobin levels in Kenyan children with Plasmodium falciparum malaria. AM J TROP MED HYG , 71 (1) pp. 43-47.

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Abstract

Heme oxygenase (HO) is thought to be induced in severe malaria, but the pathophysiologic consequences have not been examined. It is induced by hemolysis, oxidative stress, and inflammation. It degrades heme, producing carbon monoxide (CO), which causes elevated levels of carboxyhemoglobin (COHb). In a prospective study of 1,520 children admitted to a Kenyan district hospital, COHb levels were no higher in children with malaria than with other infections. The COHb levels in children with severe malarial anemia were higher than in other children with malaria, but significantly lower than in children with other causes of severe anemia such as sickle cell disease. Levels of COHb were not significantly higher in children with cerebral malaria or in those dying of malaria. These results do not support a systemic increase in HO activity in malaria compared with other infectious diseases, but the roles of HO and CO in malaria require further study

Type: Article
Title: Carboxyhemoglobin levels in Kenyan children with Plasmodium falciparum malaria
Additional information: DA - 20040707IS - 0002-9637LA - ENGPT - JOURNAL ARTICLE
Keywords: A, activity, AND, ANEMIA, ARTICLE, cell, cerebral, CHILDREN, consequences, DISEASE, DISEASES, falciparum Malaria, HEMOLYSIS, INCREASE, INFECTION, INFECTIONS, inflammation, IS, JOURNAL, Kenyan children, LA, LEVEL, Malaria, NO, OF, Other, oxidative, Oxidative Stress, Prospective Studies, PROSPECTIVE-STUDIES, Result, ROLES, sickle cell, sickle cell disease, stress, SUPPORT, SYSTEMIC, THE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/36994
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