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Irradiation of the heart during tangential breast treatment: a study within the START trial

Venables, K; Miles, EA; Deighton, A; Aird, EGA; Hoskin, PJ; (2004) Irradiation of the heart during tangential breast treatment: a study within the START trial. British Journal of Radiology , 77 (914) pp. 137-142.

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Abstract

Radiotherapy to the breast is often given as a component of the treatment for women with breast cancer. It has been shown to increase overall survival although an increase in cardiac mortality has also been noted. This study was undertaken as part of the START trial quality assurance programme to record and evaluate the cardiac dose using modern radiotherapy techniques. Departments randomizing patients into the START trial and who had CT facilities for planning breast patients were invited to take part. 62 patients were included. CT slices were taken at the level of the maximum heart depth and on the treatment field central axis. Each patient was planned in the normal way and the distributions were analysed by the quality assurance team at Mount Vernon Hospital. The maximum heart position was found to be inferior to the central axis used for breast planning for the majority of patients; mean position 2.3 cm. inferior with a mean maximum heart depth of 0.55 cm. For 45% of patients the maximum heart dose was less than 50% of the prescribed dose. The study showed that the volume of irradiated cardiac tissue has decreased compared with earlier studies, and also highlighted the need to scan away from the central axis if the dose to cardiac tissue is to be assessed

Type: Article
Title: Irradiation of the heart during tangential breast treatment: a study within the START trial
Additional information: WoS ID: 000220305600011 JournalEnglishArticle28BRITISH INST RADIOLOGY*EARL BREAST CANC, 2000, LANCET, V355, P1757; *ICRU, 1978, 29 ICRU; *START TRIAL MAN G, 1999, CLIN ONCOL, V11, P145; BROSIUS FC, 1981, AM J MED, V70, P519; CANNEY PA, 1999, BRIT J RADIOL, V72, P986; CARMEL RJ, 1976, CANCER, V37, P2813; CUZICK J, 1994, J CLIN ONCOL, V12, P447; DAS IJ, 1998, INT J RADIAT ONCOL, V42, P11; ERIKSSON F, 2000, RADIOTHER ONCOL, V55, P153; FULLER SA, 1992, RADIOTHER ONCOL, V25, P19; GUSTAVSSON A, 1999, INT J RADIAT ONCOL, V43, P745; GYENES G, 1997, J CLIN ONCOL, V15, P1348; HAYBITTLE JL, 1989, BRIT MED J, V298, P1611; HOJRIS I, 1999, LANCET, V354, P1425; HOJRIS I, 1998, RADIOTHER ONCOL S1, V48, PS120; HOST H, 1986, INT J RADIAT ONCOL, V12, P727; HURKMANS CW, 2000, RADIOTHER ONCOL, V55, P145; JANJAN NA, 1989, MED DOSIM, V14, P81; JONES JM, 1989, CLIN RADIOL, V40, P204; LANDAU D, 2001, RADIOTHER ONCOL, V60, P247; LU HM, 2000, INT J RADIAT ONCOL, V47, P895; MCENIERY PT, 1987, AM J CARDIOL, V60, P1020; NIXON AJ, 1998, J CLIN ONCOL, V16, P1374; PASZAT LF, 1999, INT J RADIAT ONCOL, V43, P755; RUTQVIST LE, 1990, BRIT J CANCER, V61, P866; SIXEL KE, 2001, INT J RADIAT ONCOL, V49, P199; VALLIS KA, 2002, J CLIN ONCOL, V20, P1036; WHELAN TJ, 2000, J CLIN ONCOL, V18, P12200FEB804NOLONDONVenables K Mt Vernon Hosp, Marie Curie Res Wing, Northwood HA6 2RN, Middx, EnglandBRIT J RADIOL36 PORTLAND PLACE, LONDON W1N 4AT, ENGLAND
Keywords: ADJUVANT RADIOTHERAPY, breast cancer, CANCER, CANCER PATIENTS, CT, HODGKINS-DISEASE, MORBIDITY, MORTALITY, POSTOPERATIVE RADIOTHERAPY, RADIATION-THERAPY, radiotherapy, SURVIVAL, TUMOR, VOLUME, WOMEN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/36749
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