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Pre-treatment haemoglobin concentration in accelerated and conventional radiotherapy for non-small cell lung carcinoma

Sibtain, A; Saunders, MI; Bentzen, SM; Hoskin, PJ; (2004) Pre-treatment haemoglobin concentration in accelerated and conventional radiotherapy for non-small cell lung carcinoma. Clinical Oncology , 16 (1) pp. 58-62.

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Abstract

Serum haemoglobin has been shown to be an independent prognostic factor for a number of cancers including head and neck, bladder, cervix and anal cancers. This study has investigated the prognostic significance of pre-treatment haemoglobin in 164 consecutive patients receiving radical radiotherapy for non-small cell lung cancer. Forty-six received conventional fractionation to 60 Gy in 30 fractions and the remainder received accelerated fractionation, either CHART, 54 Gy in 36 fractions over 12 days (27 patients) or CHARTWEL, 60 Gy in 40 fractions over 18 days (76 patients). Patients were divided into three equal groups by haemoglobin concentration. The median overall survival in each of the three groups from lowest to highest haemoglobin was 17.5 months (95%,, CI 7.9-25) 18.4 months (95% CI 15.0-25.9) and 16.3 months (95% Cl 13.0- 19.6). No significant effect of pre-treatment haemoglobin concentration was seen in predicting overall, local disease free or metastases free survival. (C) 2003 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved

Type: Article
Title: Pre-treatment haemoglobin concentration in accelerated and conventional radiotherapy for non-small cell lung carcinoma
Additional information: WoS ID: 000188201500010 JournalEnglishArticle21ELSEVIER SCIENCE LONDONBARRETTLEE PJ, 2000, BRIT J CANCER, V82, P93; CONSTANTINOU EC, 1997, INT J RADIAT ONCOL, V39, P651; DEMETRI GD, 1998, J CLIN ONCOL, V16, P3412; DISCHE S, 1986, INT J RADIAT ONCOL, V12, P1335; EVANS JC, 1965, RADIOLOGY, V84, P709; FAQUIN WC, 1992, BLOOD, V79, P1987; FEIN DA, 1995, J CLIN ONCOL, V13, P2077; FYLES AW, 2000, RADIOTHER ONCOL, V57, P13; GABRILOVE JL, 2001, J CLIN ONCOL, V19, P2875; HONG A, 1991, BRIT J RADIOL, V64, P1134; JAZIEH AR, 2000, ANN THORAC SURG, V70, P1168; JUNG C, 1984, ADV EXP MED BIOL, V180, P281; LUDWIG H, 1990, NEW ENGL J MED, V322, P1693; LUDWIG H, 1996, SEMIN ONCOL S7, V25, P2; NOWROUSAN M, 1996, RH ERYTHROPOETININ C; OEHLER W, 1990, RADIOBIOL RADIOTHER, V31, P325; QUILTY PM, 1986, RADIOTHER ONCOL, V7, P311; SAUNDERS M, 1997, LANCET, V350, P161; SAUNDERS MI, 1998, BRIT J CANCER, V78, P1323; SPIVAK JL, 1996, SEMIN ONCOL S3, V21, P3; WILHELM R, 1998, STRAHLENTHER ONKOL, V174, P1280FEB764HMLONDONHoskin PJ Mt Vernon Hosp, Marie Curie Res Wing, Northwood HA6 2RN, Middx, EnglandCLIN ONCOL-UK84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
Keywords: ACCELERATED FRACTIONATION, ANEMIA, CANCER, CARCINOMA, CERVIX, CHART, CHEMOTHERAPY PATIENTS, DISEASE, EPOETIN-ALPHA, haemoglobin, HYPOXIA, non-small cell lung cancer, QUALITY-OF-LIFE, RADIATION, radiotherapy, SURVIVAL, TRANSFUSION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/36743
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