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Evaluation of experimental models of idiopathic pulmonary fibrosis

Mutsaers, SE; McAnulty, RJ; Laurent, GJ; Knight, DA; (2004) Evaluation of experimental models of idiopathic pulmonary fibrosis. Drug Discovery Today: Disease Models , 1 (3) pp. 329-336. 10.1016/j.ddmod.2004.11.007.

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Abstract

Pulmonary fibrosis occurs in a heterogenous group of disorders and is characterised by excessive deposition of extracellular matrix proteins within the pulmonary interstitium, leading to impaired gas transfer and a loss of lung function. This review examines some models used to investigate the pathogenesis and treatment of idiopathic pulmonary fibrosis. Although no single model accurately mimics all the characteristic features of this disease most, including bleomycin, reproduce important features of the disease and provide an important tool to investigate the pathogenesis of pulmonary fibrosis. © 2004 Elsevier Ltd. All rights reserved.

Type: Article
Title: Evaluation of experimental models of idiopathic pulmonary fibrosis
DOI: 10.1016/j.ddmod.2004.11.007
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/36311
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