Gotto, J;
Dusheiko, GM;
(2004)
Hepatitis C and treatment with pegylated interferon and ribavirin.
Int J Biochem Cell Biol
, 36
(10)
pp. 1874-1877.
10.1016/j.biocel.2004.03.014.
Abstract
Hepatitis C is a hepatotropic RNA virus with a propensity to cause chronic infection, causing a worldwide burden of chronic hepatitis, cirrhosis and hepatocellular carcinoma. Both viral elimination and hepatocellular damage are thought to be immune mediated with T-helper and cytotoxic T-lymphocytes central to these events. A delay in the onset of adaptive immunity following infection indicates that a defect in the innate immune response may lead to viral persistence with a combination of other mechanisms subsequently contributing. Antiviral therapy based on interferon-alpha leads to resolution of disease in approximately 50% of patients. Specific anti-hepatitis C anti-viral drugs are being developed.
| Type: | Article |
|---|---|
| Title: | Hepatitis C and treatment with pegylated interferon and ribavirin. |
| Location: | Netherlands |
| DOI: | 10.1016/j.biocel.2004.03.014 |
| Keywords: | Hepacivirus, Hepatitis C, Humans, Interferon-alpha, Polyethylene Glycols, Recombinant Proteins, Ribavirin, Virus Replication |
| UCL classification: | UCL > School of Life and Medical Sciences UCL > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | http://discovery.ucl.ac.uk/id/eprint/36300 |
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