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Hepatitis C and treatment with pegylated interferon and ribavirin.

Gotto, J; Dusheiko, GM; (2004) Hepatitis C and treatment with pegylated interferon and ribavirin. Int J Biochem Cell Biol , 36 (10) pp. 1874-1877. 10.1016/j.biocel.2004.03.014.

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Abstract

Hepatitis C is a hepatotropic RNA virus with a propensity to cause chronic infection, causing a worldwide burden of chronic hepatitis, cirrhosis and hepatocellular carcinoma. Both viral elimination and hepatocellular damage are thought to be immune mediated with T-helper and cytotoxic T-lymphocytes central to these events. A delay in the onset of adaptive immunity following infection indicates that a defect in the innate immune response may lead to viral persistence with a combination of other mechanisms subsequently contributing. Antiviral therapy based on interferon-alpha leads to resolution of disease in approximately 50% of patients. Specific anti-hepatitis C anti-viral drugs are being developed.

Type: Article
Title: Hepatitis C and treatment with pegylated interferon and ribavirin.
Location: Netherlands
DOI: 10.1016/j.biocel.2004.03.014
Keywords: Hepacivirus, Hepatitis C, Humans, Interferon-alpha, Polyethylene Glycols, Recombinant Proteins, Ribavirin, Virus Replication
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/36300
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