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Fish as bioreactors: Transgene expression of human coagulation factor VII in fish embryos

Hwang, GL; Muller, F; Rahman, MA; Williams, DW; Murdock, PJ; Pasi, KJ; Goldspink, G; (2004) Fish as bioreactors: Transgene expression of human coagulation factor VII in fish embryos. MAR BIOTECHNOL , 6 (5) 485 - 492. 10.1007/s10126-004-3121-2.

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Abstract

A plasmid containing human coagulation factor VII (hFVII) complementary DNA regulated by a cytomegalovirus promoter was microinjected into fertilized eggs of zebrafish, African catfish, and tilapia. The active form of hFVII was detected in the fish embryos by various assays. This positive expression of human therapeutic protein in fish embryos demonstrates the possibility of exploitation of transgenic fish as bioreactors.

Type: Article
Title: Fish as bioreactors: Transgene expression of human coagulation factor VII in fish embryos
DOI: 10.1007/s10126-004-3121-2
Keywords: human coagulation factor VII, transgenic fish, bioreactor, TILAPIA OREOCHROMIS-NILOTICUS, PLASMINOGEN-ACTIVATOR, ANIMAL BIOREACTORS, BLOOD-COAGULATION, MILK, ZEBRAFISH, SEQUENCES, PROTEINS, PROMOTER, RFVIIA
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/36111
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