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Theta-modulated place-by-direction cells in the hippocampal formation in the rat

Cacucci, F; Lever, C; Wills, TJ; Burgess, N; O'Keefe, J; (2004) Theta-modulated place-by-direction cells in the hippocampal formation in the rat. J NEUROSCI , 24 (38) 8265 - 8277. 10.1523/JNEUROSCI.2635-04.2004. Green open access

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Abstract

We report the spatial and temporal properties of a class of cells termed theta-modulated place-by-direction (TPD) cells recorded from the presubicular and parasubicular cortices of the rat. The firing characteristics of TPD cells in open-field enclosures were compared with those of the following two other well characterized cell classes in the hippocampal formation: place and head-direction cells. Unlike place cells, which code only for the animal's location, or head-direction cells, which code only for the animal's directional heading, TPD cells code for both the location and the head direction of the animal. Their firing is also strongly theta modulated, firing primarily at the negative-to-positive phase of the locally recorded theta wave. TPD theta modulation is significantly stronger than that of place cells. In contrast, the firing of head-direction cells is not modulated by theta at all. In repeated exposures to the same environment, the locational and directional signals of TPD cells are stable. When recorded in different environments, TPD locational and directional fields can uncouple, with the locational field shifting unpredictably ("remapping"), whereas the directional preference remains similar across environments.

Type: Article
Title: Theta-modulated place-by-direction cells in the hippocampal formation in the rat
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.2635-04.2004
Keywords: hippocampus, spatial, orientation, navigation, path integration, maze, FREELY MOVING RATS, ANTERIOR THALAMIC NUCLEI, NEURAL-NETWORK MODEL, HEAD-DIRECTION, FIRING PROPERTIES, PYRAMIDAL CELLS, SENSORIMOTOR INTEGRATION, ENVIRONMENTAL GEOMETRY, SPATIAL NAVIGATION, PATH-INTEGRATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: http://discovery.ucl.ac.uk/id/eprint/3607
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