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New roles for integrins in squamous-cell carcinoma.

Janes, SM; Watt, FM; (2006) New roles for integrins in squamous-cell carcinoma. Nat Rev Cancer , 6 (3) pp. 175-183. 10.1038/nrc1817.

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Abstract

Although integrins are known to mediate invasion and metastasis, recent studies reveal new ways in which they contribute to squamous-cell carcinoma. Integrin mutation or upregulation can expand the tumour stem-cell compartment by inhibiting differentiation or apoptosis. Integrins that are expressed by differentiated cells can stimulate or inhibit the proliferation of neighbouring tumour stem cells. These findings provide a mechanistic basis for the well-established links between altered integrin expression and tumour prognosis.

Type: Article
Title: New roles for integrins in squamous-cell carcinoma.
Location: England
DOI: 10.1038/nrc1817
Keywords: Animals, Carcinoma, Squamous Cell, Cell Differentiation, Cell Proliferation, Humans, Integrins, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/352245
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