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Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico.

Castillo-Quan, JI; Perez-Osorio, JM; (2009) Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico. GAC MED MEX , 145 (2) 147 - 150.

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Abstract

The establishment of medical genomics in Mexico offers the possibility to study in a more comprehensive manner the etiological factors of different diseases, providing a global view of the interaction between the genome and the environment. Nutrition is recognized as a significant determinant in several diseases, yet its interaction with polymorphisms, and in general with the genome, has not been properly addressed. Mexico has a high prevalence of polymorphisms of the methylenetetrahydrofolate reductase gene, and in both clinical and basic studies this has been associated with an increased susceptibility of developing Alzheimer's disease. We propose a potential nutrigenomic approach for the study of Alzheimer disease in Mexico.

Type:Article
Title:Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico.
Keywords:Alzheimer's disease, nutrigenomics, polymorphism, homocysteine, C677T, amyloid, NEURAL-TUBE DEFECTS, MTHFR C677T POLYMORPHISM, ASSOCIATION, FOLATE, POPULATION, PREVALENCE, NUTRITION, YUCATAN, VARIANT, STATE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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