UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Structure and composition of myelinated axons: A multimodal synchrotron spectro-microscopy study

Ducic, T; Quintes, S; Nave, KA; Susini, J; Rak, M; Tucoulou, R; Alevra, M; ... Salditt, T; + view all (2011) Structure and composition of myelinated axons: A multimodal synchrotron spectro-microscopy study. J STRUCT BIOL , 173 (2) 202 - 212. 10.1016/j.jsb.2010.10.001.

Full text not available from this repository.

Abstract

We report elemental mappings on the sub-cellular level of myelinated sciatic neurons isolated from wild type mice, with high spatial resolution. The distribution of P. S. Cl, Na, K, Fe, Mn, Cu was imaged in freeze-dried as well as cryo-preserved specimen, using the recently developed cryogenic sample environment at beamline ID21 at the European Synchrotron Radiation Facility (ESRF). In addition, synchrotron radiation based Fourier transform infrared (FTIR) spectromicroscopy was used as a chemically sensitive imaging method. Finally single fiber diffraction in highly focused hard X-ray beams, and soft X-ray microscopy and tomography in absorption contrast are demonstrated as novel techniques for the study of single nerve fibers. (C) 2010 Elsevier Inc. All rights reserved.

Type: Article
Title: Structure and composition of myelinated axons: A multimodal synchrotron spectro-microscopy study
DOI: 10.1016/j.jsb.2010.10.001
Keywords: Myelin, X-ray microscopy, X-ray fluorescence, Spectromicroscopy, X-ray tomography, X-RAY-FLUORESCENCE, CENTRAL-NERVOUS-SYSTEM, ELECTRON-MICROSCOPY, SINGLE CELLS, OPTIC-NERVE, RADIATION, TOMOGRAPHY, RESOLUTION, MICROPROBE, SPECIATION
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/352025
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item