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Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma

Bower, M; Newlands, ES; Bleehen, NM; Brada, M; Begent, RJH; Calvert, H; Colquhoun, I; ... Brampton, MH; + view all (1997) Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma. CANCER CHEMOTH PHARM , 40 (6) 484 - 488.

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Abstract

Purpose: Patients with progressive or recurrent supratentorial high-grade gliomas were entered into a multicentre phase II trial to evaluate the efficacy and toxicity of temozolomide. Methods: The treatment schedule was 150-200 mg/m(2) per day orally for 5 days repeated every 28 days. Response evaluation was by a combination of neurological status evaluation (MRC scale) and imaging. Results: Of 103 eligible patients enrolled, Il (11%)achieved an objective response and a further 48 (47%) had stable disease. The median response duration was 4.6 months. Response rates were similar for anaplastic astrocytomas (grade III) and glioblastoma multiforme (grade III) rumours. Predictable myelosuppression was the major toxicity. Conclusions: The observation of objective responses and tolerable side effects in this heterogeneous population of patients supports the further investigation of this agent in high-grade gliomas.

Type: Article
Title: Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma
Keywords: glioma, temozolomide, MALIGNANT GLIOMA, ANTITUMOR IMIDAZOTETRAZINES, CHEMOTHERAPY, ADULTS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/351825
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