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A novel approach to the recognition of protein architecture from sequence using Fourier analysis and neural networks

Shepherd, AJ; Gorse, D; Thornton, JM; (2003) A novel approach to the recognition of protein architecture from sequence using Fourier analysis and neural networks. PROTEINS , 50 (2) 290 - 302. 10.1002/prot.10290.

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Abstract

A novel method is presented for the prediction of protein architecture from sequence using neural networks. The method involves the preprocessing of protein sequence data by numerically encoding it and then applying a Fourier transform. The encoded and transformed data are then used to train a neural network to recognize a number of different protein architectures. The method proved significantly better than comparable alternative strategies such as percentage dipeptide frequency, but is still limited by the size of the data set and the input demands of a neural network. Its main potential is as a complement to existing fold recognition techniques, with its ability to identify global symmetries within protein structures its greatest strength. (C) 2002 Wiley-Liss, Inc.

Type:Article
Title:A novel approach to the recognition of protein architecture from sequence using Fourier analysis and neural networks
DOI:10.1002/prot.10290
Keywords:protein fold recognition, feed-forward networks, perceptrons, power spectrum, SECONDARY STRUCTURE PREDICTION, AMINO-ACID INDEXES, BETA-TURNS, IDENTIFICATION, LOCATION, MATRICES
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
UCL > School of BEAMS > Faculty of Engineering Science > Computer Science

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